Evaluation of a new biomarker 14-3-3 Eta protein in diagnosis of rheumatoid arthritis
نویسندگان
چکیده
منابع مشابه
Serum 14-3-3-eta
Objective. Serum 14-3-3η is a novel joint-derived proinflammatory mediator implicated in the pathogenesis of rheumatoid arthritis (RA). In our study, we assessed the diagnostic utility of 14-3-3η and its association with standard clinical and serological measures. Methods. A quantitative ELISA was used to assess 14-3-3η levels. Early (n = 99) and established patients with RA (n = 135) were comp...
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15 صفحه اولA comparison of tau and 14-3-3 protein in the diagnosis of Creutzfeldt-Jakob disease.
OBJECTIVE To compare the respective efficiency of CSF tau (quantitative) and CSF 14-3-3 protein (qualitative) in the diagnosis of prion disease. METHODS We made measurements on 420 live subjects, who subsequently underwent a postmortem neuropathology examination, including protein chemistry, immunohistochemistry, and histology. We performed tau by ELISA. We detected 14-3-3 protein by Western ...
متن کاملSerum Level of 14-3-3η (Eta) Protein as a Diagnostic Marker for Rheumatoid Arthritis and Potential Correlation with Disease Activity
Results: serum 14-3-3 η levels in patients with RA (mean &SD 2.72±1.75ng/ ml) were significantly higher (P<0.0001) as compared to healthy individuals [0.09±0.09 ng/ml] and all controls [0.14±0.21ng/ml)]. For serum 14-3-3 η diagnostic accuracy in RA; ROC curve analysis comparing patient with RA with all control showed a significant AUC (P < 0.0001) and at a cutoff of ≥ 0.39 ng/ ml, the ROC curve...
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ژورنال
عنوان ژورنال: Indian Journal of Rheumatology
سال: 2020
ISSN: 0973-3698
DOI: 10.4103/injr.injr_30_20